Title of article
Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines
Author/Authors
Gichinga، نويسنده , , Moses G. and Olson، نويسنده , , Jeremy P. and Butala، نويسنده , , Elizabeth and Gilmour، نويسنده , , Brian P. and Navarro، نويسنده , , Hernلn H. and Ivy Carroll، نويسنده , , F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
2
From page
3345
To page
3346
Abstract
Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5 (mGluR5). Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.
Keywords
mGluR5 antagonist , Addiction , heterocyclic synthesis , Triazine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878610
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