Title of article :
Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines
Author/Authors :
Gichinga، نويسنده , , Moses G. and Olson، نويسنده , , Jeremy P. and Butala، نويسنده , , Elizabeth and Gilmour، نويسنده , , Brian P. and Navarro، نويسنده , , Hernلn H. and Ivy Carroll، نويسنده , , F.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5 (mGluR5). Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.
Keywords :
mGluR5 antagonist , Addiction , heterocyclic synthesis , Triazine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
