Title of article :
Stereoselective synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor
Author/Authors :
Su، نويسنده , , Jing and Tang، نويسنده , , Haiqun and McKittrick، نويسنده , , Brian A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The synthesis of a C-6 hydroxy tricyclic sulfone was described with two key reactions: the Suzuki coupling and the regioselective and stereoselective cis ring opening of the epoxide. Overall, the 14-step synthesis was achieved in 2.1% yield.
Keywords :
regioselective , Suzuki coupling , stereoselective , cis Ring opening of an epoxide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
