Nano ceria catalyzed synthesis of α-aminophosphonates under ultrasonication

A simple, efficient and general method has been developed for the one-pot three component syntheses of α-aminophosphonates. The condensation of aldehyde, amine and triethyl phosphite by employing CeO2 nanoparticles as catalyst gave α-aminophosphonates. The catalyst showed good recyclability. Nano CeO2 has been found to be an excellent catalyst for the green synthesis of α-aminophosphonates under ultrasound irradiation and solvent-free condition. The α-aminophosphonates are obtained in good to excellent yield. This catalyst provides cleaner conversion, short reaction time and high selectivity which makes the protocol feasible and economical attractive.