Title of article
Effects of nitrogen and alkene substitution on the PtCl2 catalyzed cycloisomerization of N-tethered 1,6-enyne precursors to the triple reuptake inhibitor GSK1360707
Author/Authors
Elitzin، نويسنده , , Vassil and Liu، نويسنده , , Bing and Sharp، نويسنده , , Matthew and Tabet، نويسنده , , Elie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
3518
To page
3520
Abstract
The effects of nitrogen and alkene substitution on the cycloisomerization of N-tethered 1,6-enynes into 3-azabicyclo[4.1.0]heptene precursors to the triple reuptake inhibitor GSK1360707 are described. In general, electron donating substituents proved beneficial both in terms of the reaction rate and chemoselectivity.
Keywords
Pt(II) catalysis , Nitrogen substitution effect , Alkene substitution effect , 1 , 6-Enyne cycloisomerization , Au(I) catalysis
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878680
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