Author/Authors :
Kamal Raj، نويسنده , , M. and Rao، نويسنده , , H. Surya Prakash and Manjunatha، نويسنده , , Sulur G and Sridharan، نويسنده , , R. and Nambiar، نويسنده , , Sudhir and Keshwan، نويسنده , , Jaikumar and Rappai، نويسنده , , Jayan and Bhagat، نويسنده , , Sagar and Shwetha، نويسنده , , B.S. and Hegde، نويسنده , , Dinesh and Santhosh، نويسنده , , U.، نويسنده ,
Abstract :
The mechanism of the three component base mediated Biginelli dihydropyrimidines synthesis was investigated using Accurate Mass TOF LC–MS-ESI and Tandem TOF LC–MS-ESI. We suggest hemiaminal as a possible intermediate leading to the formation of Biginelli product. Under our current experimental conditions we did not observe any bis-ureide as reported by ji et al.
Keywords :
Biginelli reaction , Dihydropyrimidine , Accurate mass TOF LC–MS-ESI , multicomponent reactions
