Author/Authors :
Aliouane، نويسنده , , Lucie and Rigaud، نويسنده , , Baptiste and Pfund، نويسنده , , Emmanuel and Jean، نويسنده , , Ludovic and Renard، نويسنده , , Pierre-Yves and Lequeux، نويسنده , , Thierry، نويسنده ,
Abstract :
The one step synthesis of difluoromethylphosphonamidates from dialkylphosphonates is reported. The addition of lithiated amides onto dialkyl difluoromethylphosphonates afforded the corresponding phosphonamidates, as potential prodrug precursors. The remarkable high stability of these phosphonamidates in acidic medium was studied by 31P NMR.
Keywords :
Difluorophosphonate , Phosphorus , Phosphonamidate , fluorine
