Title of article
Facile and stereo-controlled synthesis of 2-deoxynojirimycin, Miglustat and Miglitol
Author/Authors
Zhang، نويسنده , , Zhen-Xing and Wu، نويسنده , , Baolin and Wang، نويسنده , , Bin and Li، نويسنده , , Tie-Hai and Zhang، نويسنده , , Pengfei and Guo، نويسنده , , Li-Na and Wang، نويسنده , , Wenjun and Zhao، نويسنده , , Wei and Wang، نويسنده , , Peng George، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
3802
To page
3804
Abstract
A novel and facile synthesis of a series of the biologically significant iminosugar derivatives including 2-deoxynojirimycin, Miglustat and Miglitol is reported. The synthesis features a strategic double inversion mechanism for securing the desired stereochemistry at C5 position of such glucose-type carbohydrate mimetics, representing a practical and remarkable improvement on the previously reported method that suffers from the loss of the stereo-control during the reaction process.
Keywords
Double inversion strategy , Miglitol , DNJ , Miglustat , Mitsunobu reaction
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878803
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