Title of article
First SNAr reaction using TDAE-initiated carbanions in quinazoline series
Author/Authors
Since، نويسنده , , Marc and Khoumeri، نويسنده , , Omar and Verhaeghe، نويسنده , , Pierre and Maillard-Boyer، نويسنده , , Martine and Terme، نويسنده , , Thierry and Vanelle، نويسنده , , Patrice، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3810
To page
3813
Abstract
We report herein the first example of a SNAr reaction using TDAE-initiated carbanions in quinazoline series. The o-nitrobenzyl carbanion, formed by the action of TDAE on o-nitrobenzyl chloride, reacts with 4-chloro-2-trihalomethylquinazolines 4 and 5 via a SNAr mechanism. This enabled a new series of 4-benzyl-2-trihaloquinazoline derivatives to be synthesized in good yields under mild reaction conditions offering promising prospects for pharmacomodulation.
Keywords
TDAE , 4-Chloroquinazolines , SNAr , o-Nitrobenzyl chloride , o-Nitrobenzyl carbanion
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878807
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