Title of article :
An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
Author/Authors :
Zhang، نويسنده , , Yong-Kang and Plattner، نويسنده , , Jacob J. and Easom، نويسنده , , Eric E. and Waterson، نويسنده , , David and Ge، نويسنده , , Min and Li، نويسنده , , Zhiya and Li، نويسنده , , Lingchao and Jian، نويسنده , , Yong، نويسنده ,
Abstract :
Efficient synthesis is essential for antimalarial therapeutics. A four-step route has been established for the synthesis of 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 1 that is a potent new class boron-containing antimalarial agent in preclinical development with IC50 = 26 nM against the malaria parasite Plasmodium falciparum.
Keywords :
Synthesis , malaria , Benzoxaborole , Plasmodium Falciparum , Antimalarial therapeutics
