Author/Authors :
Nazario، نويسنده , , Carlos E.D. and Santana، نويسنده , , Amanda S. and Kawasoko، نويسنده , , Cristiane Y. and Carollo، نويسنده , , Carlos A. and Hurtado، نويسنده , , Gabriela R. and Viana، نويسنده , , Luiz H. and Barbosa، نويسنده , , Sandro L. and Guerrero Jr.، نويسنده , , Palimécio G. and Marques، نويسنده , , Francisco A. and Dabdoub، نويسنده , , Vânia B. and Dabdoub، نويسنده , , Mi، نويسنده ,
Abstract :
Sonogashira cross-coupling reactions involving (E)-iodo vinyl stannanes and terminal acetylenes were carried out in the presence of Pd(PPh3)4, CuI and several amines, affording (Z)-tributylstannyl enynes in moderate to good yields (62–91%). Utilizing the catalytic system containing Pd(PPh3)4 (5%), CuI (10%), and TBAOH (40% in aqueous media) as activator, better yields (72–91%) and lower reaction times were achieved.
Keywords :
gem-Enediyne , (E)-1-Iodovinyl-1-tributylstannanes , Sonogashira cross-coupling reactions , (Z)-Tributystannyl enynes , Tetrabutylammonium hydroxide (TBAOH)
