Title of article
Ibuprofenamide: a convenient method of synthesis by catalytic hydration of 2-(4-isobutylphenyl)propionitrile in pure aqueous medium
Author/Authors
Garcيa-ءlvarez، نويسنده , , Rocيo and Francos، نويسنده , , Javier and Crochet، نويسنده , , Pascale and Cadierno، نويسنده , , Victorio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
4218
To page
4220
Abstract
An efficient and practical synthesis of the non-steroidal anti-inflammatory drug (NSAID) ibuprofenamide by catalytic hydration of 2-(4-isobutylphenyl)propionitrile is described. The readily accessible arene-ruthenium(II) complex [RuCl2(η6-C6Me6){P(NMe2)3}] is used as the catalyst, pure water as the solvent, and microwave irradiation as the heating source.
Keywords
microwave irradiation , Ruthenium , Non-steroidal anti-inflammatory Drugs , Ibuprofenamide , Nitrile hydration
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878985
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