Author/Authors :
Sharma، نويسنده , , Sumeet K. and Bishopp، نويسنده , , Simon D. and Liana Allen، نويسنده , , C. and Lawrence، نويسنده , , Ruth and Bamford، نويسنده , , Mark J. and Lapkin، نويسنده , , Alexei A. and Plucinski، نويسنده , , Pawel and Watson، نويسنده , , Robert J. Froud-Williams، نويسنده , , Jonathan M.J. Williams، نويسنده ,
Abstract :
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)2 (1–2 mol %) was found to be effective for this transformation at 80 °C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported.
Keywords :
amide , Copper , Sustainable chemistry , Synthetic methods , Rearrangement
