Title of article
Copper-catalyzed rearrangement of oximes into primary amides
Author/Authors
Sharma، نويسنده , , Sumeet K. and Bishopp، نويسنده , , Simon D. and Liana Allen، نويسنده , , C. and Lawrence، نويسنده , , Ruth and Bamford، نويسنده , , Mark J. and Lapkin، نويسنده , , Alexei A. and Plucinski، نويسنده , , Pawel and Watson، نويسنده , , Robert J. Froud-Williams، نويسنده , , Jonathan M.J. Williams، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4252
To page
4255
Abstract
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)2 (1–2 mol %) was found to be effective for this transformation at 80 °C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported.
Keywords
amide , Copper , Sustainable chemistry , Synthetic methods , Rearrangement
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878999
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