Author/Authors :
Saikam، نويسنده , , Varma and Raghupathy، نويسنده , , Riya and Yadav، نويسنده , , Mahipal and Gannedi، نويسنده , , Veeranjaneyulu and Singh، نويسنده , , Parvinder Pal and Qazi، نويسنده , , Naveed A. and Sawant، نويسنده , , Sanghapal D. and Vishwakarma، نويسنده , , Ram A.، نويسنده ,
Abstract :
The borondipyrromethene (BODIPY) labeled new glycosylphosphatidylinositol (GPI) molecules were synthesized as cellular probes to study the chemical basis of microdomain organization of GPI-anchored proteins and cholesterol in plasma membrane. The synthesis enabled by a new stereo-selective glycosylation of myo-d-inositol acceptor led to the preparation of optically pure glucosaminyl-(1-6)-α-phosphatidyl-myo-d-inositol and its unnatural stereoisomer.
Keywords :
BODIPY fluorescent probe , Glycosylphosphatidylinositol anchors , Membrane micro-domains , Unnatural GPI analogs , d and l-myo-inositol
