Author/Authors :
Chonticha Suttibut، نويسنده , , Chonticha and Kohari، نويسنده , , Yoshihito and Igarashi، نويسنده , , Ko and Nakano، نويسنده , , Hiroto and Hirama، نويسنده , , Masafumi and Seki، نويسنده , , Chigusa and Matsuyama، نويسنده , , Haruo and Uwai، نويسنده , , Koji and Takano، نويسنده , , Nobuhiro and Okuyama، نويسنده , , Yuko and Osone، نويسنده , , Kenichi and Takeshita، نويسنده , , Mitsuhiro and Kwon، نويسنده , , Eunsang، نويسنده ,
Abstract :
An easily prepared chiral amino alcohol catalyst was found to provide an efficient synthetic intermediate of oseltamivir with excellent chemical yield and enantioselectivity (up to 98% yield and up to 98% ee) in enantioselective Diels–Alder reactions of 1,2-dihydropylidines with acroleins.
Keywords :
organocatalyst , ?-Amino alcohol , Diels–Alder reaction , 1 , 2-dihydropyridine , Isoquinuclidine
