Author/Authors :
Timmer، نويسنده , , Mattie S.M. and Dangerfield، نويسنده , , Emma M. and Cheng، نويسنده , , Janice M.H. and Gulab، نويسنده , , Shivali A. and Stocker، نويسنده , , Bridget L.، نويسنده ,
Abstract :
A remarkably efficient synthesis of the biologically important iminosugar 1-deoxygalactonojirimycin (DGJ) is presented. Key to this strategy is the development of a novel carbamate annulation reaction that favours formation of a six-membered carbamate-containing piperidine skeleton over its five-membered counterpart.
Keywords :
Carbamate , Iminosugar , iodocyclisation , synthetic methodology , total synthesis
