Title of article
Studies toward Lewis basic thiocarbamate and thiourea mediated bromolactonization: the effect of a trace amount of water on the reactivity and enantioselectivity
Author/Authors
Tan، نويسنده , , Chong Kiat and Chen، نويسنده , , Feng and Yeung، نويسنده , , Ying-Yeung and Corey، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4892
To page
4895
Abstract
The effects of trace amounts of water on thiocarbamate- and thiourea-catalyzed bromolactonization reactions are studied. It was found that the thiourea- and the N–Me thiocarbamate-catalyzed bromolactonization reactions were sensitive to trace amounts of moisture. In contrast, the N–H thiocarbamate-catalyzed bromolactonization proceeded equally smoothly in both anhydrous and non-anhydrous solvents.
Keywords
Catalysis , Water effect , Bromolactonization , Asymmetric reaction , Lewis base
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879246
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