Title of article :
A convenient synthesis of 5-fluorofuran-2-carboxylic acid
Author/Authors :
Song، نويسنده , , Renhua and Lin، نويسنده , , Weimin and Jiang، نويسنده , , Qin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A convenient synthesis of 5-fluorofuran-2-carboxylic acid has been achieved in two steps and 56% total yield. Fluorodenitration of commercially available benzyl 5-nitrofuran-2-carboxylate utilizing potassium fluoride and catalytic tetraphenylphosphonium bromide in sulfolane at 140 °C for 2 h furnished benzyl 5-fluorofuran-2-carboxylate. Hydrogenolysis of benzyl 5-fluorofuran-2-carboxylate gave the title compound.
Keywords :
5-Fluorofuran-2-carboxylic acid , Benzyl 5-nitrofuran-2-carboxylate , Benzyl 5-fluorofuran-2-carboxylate , Synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
