Author/Authors :
Ayers، نويسنده , , Sloan and Graf، نويسنده , , Tyler N. and Adcock، نويسنده , , Audrey F. and Kroll، نويسنده , , David J. and Shen، نويسنده , , Qi and Swanson، نويسنده , , Steven M. and Wani، نويسنده , , Mansukh C. and Darveaux، نويسنده , , Blaise A. and Pearce، نويسنده , , Cedric J. and Oberlies، نويسنده , , Nicholas H.، نويسنده ,
Abstract :
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC50 value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested.
Keywords :
Polyketide , cytotoxicity , Pleosporales , o-Naphthoquinone
