Title of article
Stereoselective synthesis of functionalized pyroglutamates
Author/Authors
Just، نويسنده , , Matthew J. and Tekkam، نويسنده , , Srinivas and Alam، نويسنده , , Mohammad A. and Jonnalagadda، نويسنده , , Subash C. and Johnson، نويسنده , , Joseph L. and Mereddy، نويسنده , , Venkatram R. Atigadda، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
5349
To page
5351
Abstract
Novel stereoselective synthesis of α-methylene-β-substituted pyroglutamates, and α-alkylidene-pyroglutamates has been achieved via substrate controlled asymmetric alkylation of l-threonine derived oxazole with Baylis–Hillman reaction based allyl bromides and acetates, respectively. The synthesized compounds were evaluated for their proteasome inhibition and cytotoxicity on multiple myeloma cells.
Keywords
Substrate controlled alkylation , Baylis–Hillman bromides/acetates , Pyroglutamates (?-carboxy-?-lactams) , threonine , oxazoles
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879361
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