Title of article
Synthesis of β-lactam peptidomimetics through Ugi MCR: first application of chiral Nβ-Fmoc amino alkyl isonitriles in MCRs
Author/Authors
Vishwanatha، نويسنده , , T.M. and Narendra، نويسنده , , N. and Sureshbabu، نويسنده , , Vommina V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
5620
To page
5624
Abstract
Chiral Nβ-Fmoc amino alkyl isonitriles were employed in Ugi multi component reactions (Ugi 4C-3CR) to obtain functionalized β-lactam peptidomimetics with l-aspartic acid α-methyl ester/peptide ester and organic aldehydes. The reactions were carried out in MeOH. Thirteen Ugi products have been prepared in good to moderate yields with good diastereoselectivities.
Keywords
Ugi 4C-3CR , N?-Fmoc amino alkyl isonitriles , ?-Lactam peptidomimetics , l-Aspartic acid ?-methyl ester/peptide ester
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879427
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