Title of article :
A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core
Author/Authors :
Hay، نويسنده , , Duncan A. and Adam، نويسنده , , Fiona M. and Bish، نويسنده , , Gerwyn and Calo، نويسنده , , Frederick and Dixon، نويسنده , , Rachel and Fray، نويسنده , , M. Jonathan and Hitchin، نويسنده , , James and Jones، نويسنده , , Peter and Paradowski، نويسنده , , Michael and Parsons، نويسنده , , Gemma C. and Proctor، نويسنده , , Katie J.W. and Pryde، نويسنده , , David C. and Smith، نويسنده , , Nichola، نويسنده ,
Abstract :
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents.
Keywords :
TLR7 , negishi , Carbamates , Heterocycles
