Title of article :
N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt
Author/Authors :
Kim، نويسنده , , Yongeun and Yoon، نويسنده , , Doo-Ha and Ha، نويسنده , , Hyun-Joon and Kang، نويسنده , , Kyung Yeon and Lee، نويسنده , , Won Koo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Asymmetric synthesis of MeBmt, an unusual amino acid constituent of cyclosporine A, was achieved from aziridine-(2R)-carboxaldehyde through the highly stereoselective addition of (E)-crotylboronate and the subsequent N-methylative aziridine ring opening as key steps.
Keywords :
aziridine , asymmetric synthesis , Ring opening , Crotylation , MeBmt
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
