Title of article :
A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation
Author/Authors :
Gaulier، نويسنده , , Steven M. and McKay، نويسنده , , Reuben and Swain، نويسنده , , Nigel A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A novel three linear step synthesis of Celecoxib was achieved in 33% overall yield via a key regioselective direct C–H arylation reaction between a 1,3-disubstituted pyrazole and an aryl bromide.
Keywords :
Celecoxib , Direct arylation , Pd catalysis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
