Author/Authors :
Merino، نويسنده , , Pedro and Greco، نويسنده , , Graziella and Tejero، نويسنده , , Tomلs and Chiacchio، نويسنده , , Ugo and Corsaro، نويسنده , , Antonino and Pistarà، نويسنده , , Venerando and Romeo، نويسنده , , Giovanni، نويسنده ,
Abstract :
Two monomers for the syntheses of conformationally restricted peptide nucleic acids were synthesized through a simple procedure, involving an asymmetric 1,3-dipolar cycloaddition chemistry as a key step, from common starting materials in 3 and 5 steps, and 58.8% and 30.5% overall yields, respectively.
Keywords :
Pyrrolidines , dipolar cycloaddition , Nitrones , Nucleoside analogues , peptide nucleic acids
