Title of article
Biomimetic synthetic studies on lactonamycin: an expedient synthesis of dihydroxy-isoindolinone-carboxylates
Author/Authors
Jacques، نويسنده , , Sylvain A. and Patel، نويسنده , , Bhavesh H. and Barrett، نويسنده , , Anthony G.M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6072
To page
6075
Abstract
The synthesis of dihydroxy-isoindolinone-carboxylates from a dioxinone keto-ester and N-protected sarcosine without the use of phenolic protection is described. Base-induced aromatization of the dioxinone diketo-ester followed by lactamization furnished the desired dihydroxy-isoindolinone moiety, which could be used as an EF-ring precursor toward the synthesis of lactonamycin.
Keywords
aromatization , Lactamization , Lactonamycin , C-Acylation , Dioxinones
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879536
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