Title of article :
Total synthesis of (−)-nakadomarin A: alkyne ring-closing metathesis
Author/Authors :
Jakubec، نويسنده , , Pavol and Kyle، نويسنده , , Andrew F. and Calleja، نويسنده , , Jonلs and Dixon، نويسنده , , Darren J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A 13-step, highly stereoselective synthesis of (−)-nakadomarin A has been achieved using the combination of a bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, an alkyne ring-closing metathesis/syn-reduction, and furan/iminium ion cyclization/reduction as key steps.
Keywords :
nakadomarin A , total synthesis , organocatalysis , stereoselective synthesis , Michael addition , Nitro-Mannich reaction , iminium ion , Alkyne ring-closing metathesis , Cascade
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
