Author/Authors :
Vergnaud، نويسنده , , Julien and Faugeras، نويسنده , , Pierre-Antoine and Chaleix، نويسنده , , Vincent and Champavier، نويسنده , , Yves and Zerrouki، نويسنده , , Rachida، نويسنده ,
Abstract :
We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied
Keywords :
Synthesis design , peptide nucleic acid , click chemistry , Microwave chemistry
