Title of article :
Formation of novel 1,2,3,4-tetrasubstituted 3-pyrrolines via cyclisation of γ-halo-β-ketoesters with aromatic amines and aldehydes
Author/Authors :
Brigita Cekavicus، نويسنده , , Brigita and Kore، نويسنده , , Kintija and Jakovele، نويسنده , , Liva and Plotniece، نويسنده , , Aiva and Pajuste، نويسنده , , Karlis and Petrova، نويسنده , , Marina and Belyakov، نويسنده , , Sergey and Sobolev، نويسنده , , Arkadij، نويسنده ,
Abstract :
Cyclisation of γ-halo-β-ketoesters with aromatic amines and aldehydes in methanol gave novel polysubstituted 3-pyrroline derivatives. A plausible mechanism for the reaction has been proposed. The structures of 1,2,3,4-tetrasubstituted 3-pyrrolines were confirmed by NMR spectroscopy and X-ray crystallography.
Keywords :
Cyclisation , Nitrogen Heterocycles , 3-Pyrrolines , ?-Halo-?-ketoesters
