Author/Authors :
Jalani، نويسنده , , Hitesh B. and Pandya، نويسنده , , Amit N. and Baraiya، نويسنده , , Arshi B. and Kaila، نويسنده , , Jitendra C. and Pandya، نويسنده , , Dhaivat H. and Sharma، نويسنده , , Jayesh A. and Sudarsanam، نويسنده , , V. and Vasu، نويسنده , , Kamala K.، نويسنده ,
Abstract :
Herein, we report an efficient and facile synthesis of substituted 2-aminopyrroles from the reaction of enaminone–amidine adduct and various phenacyl, benzyl, or heteroalkyl halides in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in good to excellent yields. The reaction proceeds through an intramolecular 5-exo trig cyclization resulting into diversely substituted 2-aminopyrroles.
Keywords :
2-Aminopyrroles , Enaminone , Cyanamide , N-Alkylation , 5-Exo trig
