Title of article :
Synthesis of the C21–C34 fragment of antascomicin B
Author/Authors :
Hutchison، نويسنده , , John M. and Gibson، نويسنده , , Andrew S. and Williams، نويسنده , , David T. and McIntosh، نويسنده , , Matthias C.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The C21–C34 fragment of the potent FKBP12-binding macrolide antascomicin B was prepared using Ireland-Claisen and allylic diazene rearrangements to establish the C26/C27 and the C23 stereocenters, respectively. Directed hydrogenation installed the C29 β-configuration. The fragment possesses 7 of the 11 fixed stereocenters contained in the natural product.
Keywords :
natural product , Directed hydrogenation , Ireland-Claisen rearrangement , Allylic diazene rearrangement
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
