Title of article :
Expeditious access to (−)-shikimic acid derivatives for Tamiflu synthesis
Author/Authors :
Osato، نويسنده , , Hiroshi and Jones، نويسنده , , Ian L. and Goh، نويسنده , , Huini and Chai، نويسنده , , Christina L.L. and Chen، نويسنده , , Anqi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A three-step, one-pot process has been developed for the synthesis of 5-epi-shikimic acid derivative 5 using inexpensive and abundant d-ribose as the starting material. Based on this pivotal intermediate, the syntheses of two key shikimic acid derivatives 6 and 7 for Tamiflu have been achieved in a concise and practical fashion.
Keywords :
d-ribose , Tamiflu , Shikimic acid , Ring-closing olefin metathesis , Bernet–Vasella reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
