Title of article :
Asymmetric synthesis of (−)-codonopsinine
Author/Authors :
Davies، نويسنده , , Stephen G. and Lee، نويسنده , , James A. and Roberts، نويسنده , , Paul M. and Thomson، نويسنده , , James E. and West، نويسنده , , Callum J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The asymmetric synthesis of (−)-codonopsinine was achieved in 7 steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. The key step in this synthesis involved ring-closing iodoamination of a functionalised homoallylic amine, which occurred with concomitant N-debenzylation, to give a 3-iodopyrrolidine that was elaborated to (−)-codonopsinine.
Keywords :
(?)-Codonopsinine , Ring-closing iodoamination , pyrrolidine , Lithium amide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
