Author/Authors :
Rezazgui، نويسنده , , Olivier and Boëns، نويسنده , , Benjamin and Teste، نويسنده , , Karine and Vergnaud، نويسنده , , Julien and Trouillas، نويسنده , , Patrick and Zerrouki، نويسنده , , Rachida، نويسنده ,
Abstract :
This paper describes a one-pot procedure for acetamide synthesis directly from amines and pyrimidine ester, without any catalyst or coupling agents. The inexpensive and simple reaction conditions are the most important features of this amidation. This reaction was performed with various amines, showing that long range stabilizing interactions (H-bonding and π-stacking) are the driving force for chemoselectivity.
Keywords :
Uracil acetate , DFT calculations , Amidation , Non-bonding interactions
