Title of article
A new enantioselective approach to the core structure of hypoxia selective prodrugs related to the duocarmycins
Author/Authors
Heinrich، نويسنده , , Daniel M. and Youte، نويسنده , , Jean-Jacques and Denny، نويسنده , , William A. and Tercel، نويسنده , , Moana، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
7000
To page
7003
Abstract
The indoline scaffold of hypoxia selective prodrugs of DNA-alkylating agents related to the duocarmycin natural products was synthesized via an enantioselective Friedel–Crafts alkylation. Easily accessible starting materials and good stereoselectivity in the alkylation step provide an enantioselective synthesis of the DNA-alkylating subunit.
Keywords
Prodrug , DNA alkylating , Duocarmycin , Hypoxia , enantioselective , organocatalysis
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879764
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