Title of article
Ikirydinium A: a new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)
Author/Authors
Ajala، نويسنده , , Olusegun S. and Piggott، نويسنده , , Andrew M. and Plisson، نويسنده , , Fabien and Khalil، نويسنده , , Zeinab and Huang، نويسنده , , Xiao-cong and Adesegun، نويسنده , , Sunday A. and Coker، نويسنده , , Herbert A.B. and Capon، نويسنده , , Robert J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
7125
To page
7127
Abstract
Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.
Keywords
Hunteria umbellata , Nigerian medicinal plant , Indole alkaloids , Natural products chemistry
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879793
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