Author/Authors :
Ajala، نويسنده , , Olusegun S. and Piggott، نويسنده , , Andrew M. and Plisson، نويسنده , , Fabien and Khalil، نويسنده , , Zeinab and Huang، نويسنده , , Xiao-cong and Adesegun، نويسنده , , Sunday A. and Coker، نويسنده , , Herbert A.B. and Capon، نويسنده , , Robert J.، نويسنده ,
Abstract :
Chemical investigations into samples of Hunteria umbellata (K. Schum) collected in Osun State, Nigeria, led to the discovery of a new indole alkaloid, ikirydinium A, featuring an unprecedented 3-alkylpyridinium-indole-2-carboxylate scaffold. Ikirydinium A was found to exhibit antimicrobial activity (IC50 0.6 μM) against Bacillus subtilis ATCC 6051. The involvement of a common intermediate in the biosynthesis of ikirydinium A and vinblastine is hypothesized.
Keywords :
Hunteria umbellata , Nigerian medicinal plant , Indole alkaloids , Natural products chemistry
