Title of article :
Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives
Author/Authors :
Raheem، نويسنده , , K. Saki and Botting، نويسنده , , Nigel P. and Williamson، نويسنده , , Gary and Barron، نويسنده , , Denis، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
We report the first total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives, 3,5-O-diferuloylquinic acid and 3,5-(3,4-dimethoxycinnamyl)quinic acid, in a nine-step sequence. The key step involves Knoevenagel condensations between vanillin, 3,4-dimethoxybenzaldehyde or 4-hydroxy-3-methoxybenzaldehyde and the dimalonate ester of quinic acid.
Keywords :
Dicaffeoylquinic acids , natural product synthesis , Knoevenagel condensation , Metabolism references , Plant natural products
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
