Title of article :
Azaindolines: derisking the indoline structural alert
Author/Authors :
Piatnitski Chekler، نويسنده , , Eugene L. and Khan، نويسنده , , Taukeer A. and Mamidala، نويسنده , , Rajanikanth and Anderson، نويسنده , , James T. and Tangirala، نويسنده , , Raghuram S. and Verhoest، نويسنده , , Patrick R. and Gilbert، نويسنده , , Adam M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
4-Substitued azaindolines, which are isosteres of indolines, are useful synthetic building blocks that reduce the risk of bioactivation induced idiosyncratic toxicity have been prepared. Multigram routes to 2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-4-triflate 16, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile 20 and 4-chloro-2,3-dihydro-1H-pyrrolo[2,3-d]pyridazine 30 are outlined.
Keywords :
Azaindoline , Indoline , Structure alert , Aniline
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
