Synthetic studies toward MPC1001: preparation of a β-hydroxyl-tyrosine derivative

A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid derivative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde.