Title of article :
Stereoselective synthesis of analogs of the macrolactone of isomigrastatin
Author/Authors :
Dias، نويسنده , , Luiz C. and Monteiro، نويسنده , , Gustavo C. and Amarante، نويسنده , , Giovanni W. and Conegero، نويسنده , , Leila S. and Finelli، نويسنده , , Fernanda G.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
An approach for the highly stereoselective synthesis of analogs of the macrolactone of isomigrastatin is described. Our optimized strategy is based on a very efficient lactone opening, a Wittig olefination reaction and a ring closing metathesis. The syntheses were accomplished in 10–11 steps and good overall yields.
Keywords :
Dihydroxilation reaction , Ring closing metathesis , macrolactone , Tumor metastasis , Migrastatin
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
