Title of article
High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles
Author/Authors
Reichart، نويسنده , , Benedikt and Kappe، نويسنده , , C. Oliver، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
952
To page
955
Abstract
Applying continuous flow processing in a high-temperature/high-pressure regime (200–220 °C, 11–14 bar) 2,5-disubstituted-1,3,4-oxadiazoles are prepared in high yields within 5–10 min residence time by treatment of 5-substituted-1H-tetrazoles with anhydrides or acid chlorides as electrophiles (Huisgen reaction).
Keywords
Continuous flow synthesis , Heterocycles , Microwave-assisted synthesis , Process intensification , Microreactors
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880147
Link To Document