Title of article
Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors
Author/Authors
Tite، نويسنده , , Tony and Tomas، نويسنده , , Loic and Docsa، نويسنده , , Tibor and Gergely، نويسنده , , Pal and Kovensky، نويسنده , , José and Gueyrard، نويسنده , , David and Wadouachi، نويسنده , , Anne، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
959
To page
961
Abstract
A new C-glucosylated spiro-sulfamide has been prepared and evaluated toward glycogen phosphorylase inhibition. The synthesis was carried out successfully by nucleophilic displacement of 1-O-tosyl or 1-deoxy-1-iodo-α-d-gluco-hept-2-ulopyranose tetra-O-benzylated derivative using aryl amines, followed by the formation of the corresponding cyclic sulfamide.
Keywords
exo-glucal , Spiro-sulfamide , Gluconolactone , Burgess reagent
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880151
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