Author/Authors :
Gross، نويسنده , , Timothy and Chou، نويسنده , , Shine and Dyke، نويسنده , , Alan and Dominguez، نويسنده , , Beatriz and Groarke، نويسنده , , Michelle and Medlock، نويسنده , , Jonathan and Ouellette، نويسنده , , Michael and Reddy، نويسنده , , Jayachandra P. and Seger، نويسنده , , Andreas and Zook، نويسنده , , Scott and Zanotti-Gerosa، نويسنده , , Antonio، نويسنده ,
Abstract :
The asymmetric hydrogenation of a pyridyl benzothiophene alkene has been successfully accomplished using [BoPhoz Rh] catalysts. By tailoring the steric properties of the BoPhoz ligand, the ee of the product could be increased from just 12% to 90%. This research further expands the substrate scope of the conventional class of functionalized alkenes amenable to catalytic asymmetric hydrogenation.
Keywords :
Homogeneous asymmetric hydrogenation , Enantioselective hydrogenation of alkenes , BoPhoz ligands , rhodium catalysts
