Title of article
Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines
Author/Authors
Muthusaravanan، نويسنده , , Sivasubramanian and Perumal، نويسنده , , Subbu and Almansour، نويسنده , , Abdulrahman I.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
1144
To page
1148
Abstract
The pseudo five-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-one, formaldehyde and aniline afford 5-aroyl-1,3-diarylhexahydropyrimidines in good yields under catalyst-free conditions. This transformation involving 4 C–N and 1 C–C bond formations in a one pot operation presumably proceeds via Michael addition–elimination–Mannich type reaction-condensative annulation–reduction sequence.
Keywords
Domino reaction , (E)-3-(Dimethylamino)-1-arylprop-2-en-1-one , Formaldehyde , 5-Aroyl-1 , Aniline , 3-diarylhexahydropyrimidines
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880208
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