Title of article
A chemoselective hydroxymethylation: new route for the synthesis of 6-aroyl-4-(4H-triazol-3-yl)thiomorpholin-3-ones
Author/Authors
Krishnaraj، نويسنده , , Thulasiraman and Muthusubramanian، نويسنده , , Shanmugam، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1149
To page
1152
Abstract
Treatment of 2-(2-oxo-2-arylethylthio)-N-(4H-1,2,4-triazol-3-yl)acetamides with paraformaldehyde in the presence of a base has led to a tandem chemoselective hydroxymethylation followed by cyclization yielding a set of novel 6-aroyl-4-(4H-triazol-3-yl)thiomorpholin-3-ones. The thiomorpholine ring has been found to have a boat like conformation in these compounds as evidenced by NOESY NMR spectrum.
Keywords
Chemoselective hydroxymethylation , Paraformaldehyde , 6-Aroyl-4-(4H-triazol-3-yl)thiomorpholin-3-one , Tandem cyclization , Boat conformation
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880209
Link To Document