Title of article
A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles
Author/Authors
Su، نويسنده , , Zhaoming and Peng، نويسنده , , Lingling and Melander، نويسنده , , Christian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
1204
To page
1206
Abstract
Diversified 1,4,5-substituted-2-aminoimidazoles were rapidly assembled via sequential N–H insertion and Grignard addition to α-diazoesters. Lead compounds were identified as antibiotics against Gram-positive bacteria with an MIC value as low as 2 μg/mL.
Keywords
N–H insertion , 2-aminoimidazole , antibiotic , heterocycle , Polysubstitution
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880224
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