Title of article :
A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles
Author/Authors :
Su، نويسنده , , Zhaoming and Peng، نويسنده , , Lingling and Melander، نويسنده , , Christian، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Diversified 1,4,5-substituted-2-aminoimidazoles were rapidly assembled via sequential N–H insertion and Grignard addition to α-diazoesters. Lead compounds were identified as antibiotics against Gram-positive bacteria with an MIC value as low as 2 μg/mL.
Keywords :
N–H insertion , 2-aminoimidazole , antibiotic , heterocycle , Polysubstitution
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
