Title of article
The first examples of seco-prezizaane-type norsesquiterpenoids with neurotrophic activity from Illicium jiadifengpi
Author/Authors
Kubo، نويسنده , , Miwa and Kobayashi، نويسنده , , Kana and Huang، نويسنده , , Jian-Mei and Harada، نويسنده , , Kenichi and Fukuyama، نويسنده , , Yoshiyasu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
1231
To page
1235
Abstract
Two seco-prezizaane-type sesquiterpenoids (2R)-hydroxy-norneomajucin (1) and jiadifenone (2) that represent the first examples of nor-type were isolated from the methanol extract of the pericarps of Illicium jiadifengpi. Their structures and the absolute configuration of 1 were established by the analysis of spectroscopic data and chemical conversion of (2S)-hydroxyneomajucin to 1, respectively. In addition, compound 1 exhibited neurotrophic activity to significantly promote neurite outgrowth in the primary cultured rat cortical neurons at concentrations ranging from 1 to 10 μmol L−1.
Keywords
(2R)-Hydroxy-norneomajucin , Jiadifenone , seco-Prezizaane , Norsesquiterpenoid , Neurotrophic activity
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880231
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