Author/Authors :
Ni، نويسنده , , Lijun and Li، نويسنده , , Ziyuan and Wu، نويسنده , , Fan and Xu، نويسنده , , Jinyi and Wu، نويسنده , , Xiaoming and Kong، نويسنده , , Lingyi and Yao، نويسنده , , Hequan، نويسنده ,
Abstract :
The first concise total syntheses of pyrroloquinoline natural products, Marinoquinolines A–C, have been achieved in six linear steps from commercially available starting materials. The key steps were a reaction between (p-tolylsulfonyl)methylisocyanide (TosMIC) and α, β-unsaturated ester under basic condition to prepare the pyrrole moiety and Morgen-Walls reaction to construct quinoline ring.
Keywords :
natural product , Marinoquinoline , antitumor , total synthesis , Pyrroloquinoline
