Title of article
Pd-catalysed amidation of 2,6-dihalopurine nucleosides. Replacement of iodine at 0 °C
Author/Authors
Bosch، نويسنده , , Lluيs and Cialîcu، نويسنده , , Ionela and Caner، نويسنده , , Joaquim and Ariza، نويسنده , , Xavier Pérez Costa، نويسنده , , Anna M. and Terrazas، نويسنده , , Montserrat and Vilarrasa، نويسنده , , Jaume، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
1358
To page
1362
Abstract
Pd-catalysed reactions of 2-Cl, 2-Br and 2-I derivatives of a 6-chloropurine nucleoside with benzamide have been compared, using Pd2dba3, Xantphos and Cs2CO3 in toluene, between 20 and 80 °C. The reactivity order was 2-I > 2-Br > 6-Cl ≫ 2-Cl. The 2-I substituent could be replaced even at 0 °C, under conditions disclosed here for the first time. On the other hand, the replacement of the chlorine atom at position 2 (2-Cl) required 110 °C.
Keywords
Pd insertions at 0 , 2 , °C , 6-Diaminopurine derivatives , C–N bond formation
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880261
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