Title of article :
Synthetic studies toward biselides. Part 1: synthesis of the core carbon framework of biselides A, B, and E using Stille coupling
Author/Authors :
Satoh، نويسنده , , Yohsuke and Kawamura، نويسنده , , Dai and Yamaura، نويسنده , , Masashi and Ikeda، نويسنده , , Yoichi and Ochiai، نويسنده , , Yumi and Hayakawa، نويسنده , , Ichiro and Kigoshi، نويسنده , , Hideo، نويسنده ,
Abstract :
Biselides A and B are cytotoxic marine polyketides. We have achieved synthesis of the C-1–C-15 segment of biselides A and B by using Stille coupling and regioselective oxidative cleavage as key steps. Furthermore, we constructed the α,β-unsaturated lactone part of biselide E by using a similar strategy.
Keywords :
Biselides , polyketides , Stille coupling , Regioselective oxidative cleavage
