Flow microreactor synthesis of tricyclic sulfonamides via N-tosylaziridinyllithiums

Tricyclic sulfonamides were synthesized by the generation of aziridinyllithiums from N-tosylaziridines followed by an intramolecular nucleophilic reaction and the subsequent reaction with electrophiles using a flow microreactor system. The reactions could be carried out at 0 °C, although much lower temperatures such as −78 °C are needed for batch macro reactors.